Andy Burnham will hold his first meeting at the new No 10 North in Manchester later on Friday.
The branch of Downing Street in the North West will form part of the prime minister’s aim to shift power from Whitehall and Westminster to regions across the country.
Ministers Lucy Powell and Louise Haigh will also operate regularly from the new site, with up to 300 civil servants expected to join them by the end of next year.
On Friday in Manchester, Burnham will chair a meeting of the National Economic Council, a cabinet committee first launched in 2008 to respond to economic challenges around the UK.
The meeting will bring together senior ministers and regional mayors to “put devolution at the centre of the government’s mission to make Britain better”.
Ahead of that meeting, the prime minister said: “For 40 years, power and resources have been sucked into the centre, and too many communities have felt forgotten, without the attention and investment they deserve.”
He added: “The days of Whitehall resisting devolution are over, for good.”
Strategic decisions about devolution and local economic growth will shift from the Treasury and the Ministry of Housing, Communities and Local Government to No 10 North, although both departments will have input in these areas.
Angela Rayner, whose constituency is in Greater Manchester, is also expected to work from the new site for the first time on Friday.
Asked whether Burnham’s messaging was too focused on the north of England, Rayner told BBC Breakfast people understood No 10 North was about driving growth in every postcode across the UK.
